• 专利附录
  • 专利说明
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    • 专利摘要:
    1486288 Sustained release of medicaments COMMISSARIAT A L'ENERGIE ATOMIQUE 4 Nov 1974 [9 Nov 1973] 47545/74 Heading A5B [Also in Division C3] A hydrophobic polymeric substrate has cross-linked polymerised hydrophilic inclusions derived from an hydrophilic ethylenically unsaturated monomer grafted to the substrate and distributed throughout the volume thereof and has a medicament, soluble in polar solvents, stored in said inclusions and desorbable therefrom on contacting the hydrophobic polymeric substrate with a polar solvent.
    公开号:SU1060119A3
    申请号:SU742075365
    申请日:1974-11-06
    公开日:1983-12-07
    发明作者:Госсан Жильбер；Лемэр Франси
    申请人:Коммиссариат А Лъэнержи Атомик (Фирма)；
    IPC主号:
    专利说明:

    CO. The invention relates to a process for the production of polymeric absorbing substrates and can be used in the chemical industry. A known method for producing a polymer absorbing substrate by introducing polymer hydrophilic inclusions into a polymer hydrophobic substrate consists in mixing an inert hydrophobic polymer with a powdered filler followed by processing the substrate obtained from a mixture of a substrate, for example, video film, with a solvent for the filler. Hydrophilic monomer Clil is grafted under the action of ionizing irradiation onto the obtained substrate containing cavities, after dissolving the filler particles incorporated into the substrate. However, the known method does not allow to obtain the target products containing reversibly absorbed substances with a controlled rate to desorption. According to the invention, a method for producing a polymer substrate-solvent containing reversible substances, which consists in that a copolymer of ethylene and vinyl acetate as a polymer hydrophobic substrate is subjected to swelling in aqueous, alcoholic or aqueous-alcoholic solutions of acrylate ethylene glycod or its mixture with diacrylates ethylene glycols as a hydrophilic monomer in the presence of copper acetate as a polymerization inhibitor and followed by grafting to the substrate of the monomer under the action of - and radiation, The resulting product is isolated from the solution and treated with aqueous solutions of copper nitrate or sulfate as an absorbable substance. . In addition, a second variant of the method is that the absorber substrate recovered from the solution is irradiated a second time by - rays. P RIM er 1, Hydrophobic, a substrate (copolymer of vinyl acetate and ethylene) is introduced into a pyrex vessel containing a mixture of 25 wt.% Ethylene glycol acrylate and 75 wt.% Water, in which 2 wt.% Copper acetate and 2 wt. % copper for inhibition of the homopolymerization of the monomer. Double degassing of the vessel contents is carried out and exposed to the y-rays of the Co source. During irradiation, the vessel is maintained at a constant temperature of 45 ° C in a liquid thermostat. The dosage is 0.2 mrad / h, the dose is 1.4 mrad. After irradiation, the substrate is washed, dried, weighed, conversion 22.6%. Then, the copper nitrate is sampled by a substrate containing grafted hydrophilic inclusions of ethylene glycol acrylate. The absorption is carried out in a solution of copper nitrate at a concentration of 5000 g / l. Salting of copper ions with a substrate loaded and treated with an isotonic solution with a dosage of 400 cm. Vde.n reaches 60-20 mg / day. EXAMPLE 2 In the second example, the same method and the same substrate as in example 1 are used, and the solution introduced into the tank contains,%: ethylene glycol acrylate 20) diethylene glycol diacrylate (network forming agent) .5) methanol 75. 1% copper acetate and 0.5% powdered copper (inhibitor) are added to it. The temperature during irradiation is 40 ° С, the dosage is 0.1 mrad / h and the dose is 1.4 mrad. Conversion is 26%, and the rate of copper nitrate intake when the substrate being treated is placed in a solution with a concentration of 5000 g / l is lower than in Example 1, which results in a slower desorption of the same salt in the solution. Froze Substances grafted according to Example 1 are placed in a nitrogen atmosphere and irradiated with rays at a dose of 0.4 mrad / h at doses of 6.4; 9.6; 19.2 mrad After copper nitrate has been collected for 138 hours more, each substrate is 25%. Salting out products (copper nitrate) in an isotonic solution is more significant for a substrate with a network that forms, at 6.4 mrad, than for a substrate with a network that forms, at 9.6 and 19.2 mrad, which indicates the formation of a network . Example 4. A hydrophobic substrate (a copolymer of vinyl acetate and ethylene) is introduced into a vessel containing,%: ethylene glycol 40 acrylate; water 46) diethylene glycol diacrylate 10 (a network-forming agent), copper acetate 2, powdered copper 2. Then the process, as indicated in example 1, is carried out in a liquid thermostat at 40 ° C. Conversion is 26% and the degree is in-. hurt, i.e. the weight percentage of copper nitrate reaches 11% after immersing the treated substrate in a solution of copper nitrate with a concentration of 5000 g / l. Example 5. In a substrate containing inclusions, as in example 1,
    copper sulphate is injected by immersing the packed substrate into a solution with a concentration of 1000 g / l for 20 hours. The weight gain of the substrate is 6%.
    Example A substrate prepared as in example 1 is taken, copper is injected in the form of inclusions before irradiation using a solution in which 75% of water
    contain copper nitrate at a concentration of 5000 g / l.
    Thus, the proposed method makes it possible to obtain polymeric absorbing substrates containing reversibly absorbable substances — copper salts — which makes it possible to use them as catalysts for reactions in liquid polar media.
    权利要求:
    Claims (2)
    [1]
    1. METHOD FOR PRODUCING A POLYMERIC SUBSTRATE-ABSORBER containing reversibly absorbable substances, the key is that the copolymer of ethylene with vinyl acetate as a polymer hydrophobic substrate is swollen in water, alcohol or water-alcohol solutions of ethylene glycol acrylate or a mixture thereof with ethylene glycol diacrylates as a hydrophilic monomer in the presence of copper and copper acetate polymerization inhibitors, followed by grafting of the monomer to the substrate under the influence of γ-radiation, obtained odukt separated from the solution and treated with water nitrate or copper sulfate solution as an absorbent material.
    [2]
    2. The method according to π. 1, with the fact that the substrate-absorber isolated from the solution is irradiated with y-rays a second time.
    frlioeorns *>
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    同族专利:
    公开号 | 公开日
    CA1049954A|1979-03-06|
    IL46010A|1978-09-29|
    FR2250793A1|1975-06-06|
    DE2453155A1|1975-05-15|
    IL46010D0|1975-05-22|
    SE7414081L|1976-05-10|
    IT1024789B|1978-07-20|
    ES431778A1|1977-05-16|
    DE2453155C2|1986-01-30|
    NL164874B|1980-09-15|
    BE821909A|1975-03-03|
    CH606208A5|1978-10-31|
    FR2250793B1|1978-12-29|
    GB1486288A|1977-09-21|
    JPS5639780B2|1981-09-16|
    NL7414588A|1975-05-13|
    SE419967B|1981-09-07|
    NL164874C|1981-02-16|
    ZA747123B|1976-03-31|
    JPS50112479A|1975-09-03|
    引用文献:
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    FR2056057A5|1969-08-26|1971-05-14|Raffinage Cie Francaise|
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    JPS6152178B2|1977-12-02|1986-11-12|Teijin Ltd|
    FR2433949B1|1978-08-25|1982-10-22|Commissariat Energie Atomique|
    DE2930321A1|1978-09-25|1980-04-10|Jenapharm Veb|METHOD FOR PRODUCING A NEW PHARMACEUTICAL AUXILIARY SUBSTANCE AND SOLID MEDICINES PRODUCED THEREOF|
    JPH0323530B2|1979-03-21|1991-03-29|Nat Res Dev|
    EP0033262B1|1980-01-29|1986-12-30|Elf Atochem S.A.|Electrolysis diaphragm and method for its manufacture|
    FR2485370B1|1980-06-30|1984-01-06|Commissariat Energie Atomique|
    FR2505879B1|1981-05-15|1985-09-27|Chloe Chemie|DIAPHRAGM, ITS PREPARATION METHOD AND THE ELECTROLYSIS METHOD USING THE SAME|
    FR2513256A1|1981-09-18|1983-03-25|Commissariat Energie Atomique|ELASTOMER SEPARATOR ELEMENT, PROCESS FOR PREPARING THE SAME AND USE THEREOF IN HYDROPNEUMATIC SUSPENSION SYSTEMS|
    JPS5969570U|1982-10-29|1984-05-11|
    US4695592A|1986-01-07|1987-09-22|Mitsubishi Rayon Co., Ltd.|Hydrophilized porous membrane and production process thereof|
    GB2186485B|1986-02-13|1988-09-07|Ethical Pharma Ltd|Slow release formulation|
    US4897433A|1986-12-08|1990-01-30|Japan Atomic Energy Research Inst.|Process for producing an anti-thrombogenic material by graft polymerization|
    US4906374A|1986-12-23|1990-03-06|Pall Corporation|Filtration media with low protein adsorbability|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    FR7340002A|FR2250793B1|1973-11-09|1973-11-09|
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